Surface modification of silicate, borosilicate and phosphate bioactive glasses to improve/control protein adsorption: PART I

Bioactive glasses (BGs) are promising for bone tissue regeneration. BG composition can be tailored, according to the application of interest, and/or functionalized with organic molecules/biomolecules improve their performances. However, despite wide knowledge concerning BGs, interaction proteins, fundamental controlling fate implant, has not been deeply investigated yet. Controlling or predicting protein adsorption requires a full understanding materials surface physico-chemical properties. In this work, four different BGs (S53P4, B25, SCNB, PhGlass) were surface-modified by treatments: 72 h-soaking in TRIS, h soaking simulated body fluid, APTES grafting and quaternized grafting. The surfaces then characterized both untreated after each treatment contact angle, zeta potential analysis, X-ray photoelectron spectroscopy, Fourier Transform InfraRed–Attenuated Total Reflectance spectroscopy Scanning Electron Microscopy Energy Dispersive Spectroscopy. Inductively Coupled Plasma – Optical Emission Spectrometry was performed investigate ion leaching. aim study (Part I) is characterization as function implemented treatments, aiming better understand how superficial properties successively affecting adsorption. Protein on treated will discussed following manuscript II).